It isn’t particularly dangerous. In fact, it’s especially safe as long as you edit your files within DEVONthink To Go (DTTG).
Things get a little weird if you also sync your indexed folder through a different sync service (e.g., you keep it in Dropbox). If you edit this file to iOS outside of DEVONthink (e.g., you open it in Dropbox and make a change), the following needs to happen before you can see the change on DEVONthink To Go:
- The file syncs to Dropbox from your iOS device.
- DEVONthink on your Mac needs to be open, and then it will pick up the change to the indexed file on some semi-random schedule (although it is fairly frequently)
- DEVONthink to Go needs to be opened and then synced with DEVONthink on the Mac.
This is a kind of round-tripping, and can be annoying. But again, if you edit everything in DTTG, you’re set.
Another caveat, though, is that while Obsidian and DEVONthink on the Mac recognize [[links]], DEVONthink To Go does not. So your links will be dead on iOS even though they work on the Mac.