@sirlaughalot I think it is difficult to find a guide, if at all, precisely because note-taking is so personal. I think (sorry to use that term again) the best way is to 1st decide what your note-taking objective is, then to read up about it.
For example, if your objective is to create a zettelkasten, you read up what you can find. If you need an efficient system (time and quality wise) to take notes in class you could read up about the Cornell system, or other systems. If journaling is your objective read up about the Bullet Journal or another one, and so on.
I 1st had 1 objective: a zettelkasten. I read a lot, discussed on the zettelkasten.de forum, then looked for a suitable app. I managed to put together a collection of 400 notes using a number of apps, none of which I was really happy with. I think I have found it with Obs.
While I was collecting those zk notes, I developed a need for a 2nd collection: notes about geopolitical issues and developments. But …… those evolved into rather long notes, so I broke the “atomicity” principle. I am OK with that, although I sometimes wonder if I could get more out of them if they were split into much smaller units. That, however, would take too much time to implement, time I am not prepared to spend so I keep them as they are. When Obs becomes more mature with a few more features I need (e.g. the in-doc ToC for my long notes), I will probably transfer the folders to an Obs vault, because ideally I want to have just 1 markdown note-taking app.