I’ve set it up in Kasm (container streaming to the browser). I think it’s doable but not in the same way that Notion can. There would have to be an incredibly complex layer or API overhaul to allow for certain community plugins to work just for the browser version. Kasm and VNC and remote desktop gateways + browser are really the only way to access Obsidian as it currently is (from the browser).
I’ve got a workspace in my vault where I’m playing around with these ideas. I’m an InfoSec manager and love Obsidian but it presents potential privilege escalation and third-party code issues (plugins).
If you want to account for the glaring plugin trust issue, then you need a PAM system, or application whitelisting solution, and/or file permissions to make it so that there is a way to approve and whitelist plugin files in the “plugins” directory. This is something I’m trying to figure out how to do in the next several months.