I lied, one more! sorry. 
In this example, you’re looking only in the People folder, except notes tagged “coworker”
path:“People” -tag:#coworker
What about other scenarios? E.g. look in People, but only those tagged w/ “coworker” (I assume just take out the minus sign), or search the whole database for “coworker” except in the folder “Fired for insubordination”