Many people (including myself) prefer to use separate vaults for separate concerns, and it’s not always easy to figure out where the line should be. I have three primary vaults for my work, reference, and personal life, as well as individual vaults for creative endeavors.
Other people prefer to keep everything in one vault for easy reference and linking. I think both are valid approaches, so you may have to experiment to find out what works best for you.
There was a good discussion on this topic a few years ago you might find helpful:
There was also another discussion, a bit more about “what are vaults for”, that you might find interesting:
If you have more specific questions please ask; most folks are usually happy to talk about their approaches. Good luck!